MALARIA AND IMMUNE SYSTEM: BALANCING PROTECTION VERSUS PATHOLOGY: Review Article
HANAA Y. BAKIR
Department of Parasitology, Faculty of Medicine, Assiut University, Egypt
Malaria is a parasitic infection of global importance which is responsible for millions of deaths in tropical countries. It remains one of the most prevalent infections of humans worldwide. Immune responses limit the clinical impact of infection and provide partial protection against pathogen replication. However, these complex immunological reactions can contribute to disease and fatalities. So, appropriate regulation of immune responses to malaria lies at the heart of host-parasite balance and current efforts to control malaria focus on reducing attributable morbidity and mortality. This review addresses innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities. Moreover, it determined the pivotal role of cellular effectors, molecules and cytokines involved in activation of immune response at different stages of human malaria and considered implications for vaccine design.