ROLE OF CURCUMIN FOR REGULATION THE EFFECT OF THE IMMUNE SYSTEM ON HEPATIC FIBROSIS IN EXPERIMENTAL RATS
Adham Gamal Sadiq* and KH. M. Zakaria**
*Zoology Department , Faculty of Science , Al-Azhar University, Cairo , Egypt**National Center for Nuclear Safety and Radiation Control, Egyptian Atomic Energy Authority, Cairo, Egypt
Chronic liver diseases, such as fibrosis or cirrhosis, are more common in men than in women. The aim of the present study was to investigate the role of curcumin for regulation the immune system in hepatic fibrosis in experimental rats, and also investigate the suppressive effect of curcumin on hepatic fibrosis in rats induced by CCl4 injections. Chronic intermittent injection of carbon tetrachloride (CCl4) for more than 6 weeks induced liver fibrosis in rats. All groups except the first and second groups were injected i.p with CCl4 at a dose of 3 ml /kg body weight twice a week for six weeks accompanied with treatment of curcumin at different doses of 250,200 and 150 mg/ kg body weight. The first group was injected with saline as control; also the second group was injected with CCl4 alone without treatment. All groups were sacrificed after 6 weeks and investigated with the immunoresponse (cytokine) IL-10 and proinflammtory cytokines TNF–alpha and TGF-1β paralleled with histopathological study for liver tissues and liver enzymes (ALT, AST). The results of the current study revealed that the level of IL-10 was decreased significantly in the group received CCl4 alone, On the other hand, groups treated with curcumin recorded significant increase in IL-10 level. TNF – alpha and TGF-1β were increased significantly in the group received CCl4 alone, but the groups treated with curcumin revealed a significant decrease.