EFFECT OF GARLIC (ALLIUM SATIVUM ) EXTRACT ON SOME PHYSIOLOGICAL PARAMETERS IN RATS TREATED WITH LEAD ACETATE
Mostafa I. Badr
Department of Animal Physiology, Animal Production, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.
This study was designed to evaluate the protective effect of garlic against lead toxicity. A total of 32 male albino rats were distributed into 4 groups, 8 rats each, assigned into four treatment groups: (1) control, (2) garlic extract 1 ml /100 g BW, (3) lead 3 mg /100 g BW, (4) 1 ml of garlic extract/100 g (BW) plus 3 mg lead/100 g BW. Rats were orally administered their respective doses every other day for 30 days. Blood samples were collected at 15 and 30 days from the start of treatments. Results showed that oral administration of lead significantly increased plasma ALT, AST, cholesterol, triglycerides, LDL-cholesterol and glucose and significantly decreased blood hemoglobin, hematocrit and plasma HDL-cholesterol. Oral administration of garlic in combination with lead acetate alleviated some of its toxic effects which were recognized from retaining the levels of the studied plasma parameters either up or down, near the normal levels of the control group.Conclusion: Garlic has beneficial effects and ability to prevent some toxic effects of lead.