EVALUATION OF MICROVASCULAR DENSITY IN SUPERFICIAL AND INVASIVE TRANSITIONAL CELL CARCINOMA OF THE HUMAN URINARY BLADDER
Sherif M. Sabry *, Wael Shawky **, Mostafa Salem **, and Vector Boulous***
Departments of Anatomy* and Pathology**, Faculty of Medicine, Cairo University.Department of Urosurgery***, El-Sahel Teaching Hospital
Neoangiogenesis is assumed to play an important role in progression, prognosis and metastasis of a wide variety of tumors. Microvascular density (MVD) is a marker for tumor angiogenesis have been demonstrated in 52 case of superficial and deep transitional cell carcinoma of the human urinary bladders obtained by transurethral resection biopsy and subjected to routine histopathological examination and grading of the tumor with assessment of muscle invasion. Immunohistochemical staining of the endothelial cells was done by monoclonal antibody against CD31antigen. MVD was evaluated and correlated with grading, staging and recurrence of superficial and invasive transitional cell carcinoma of the urinary bladder. It was found that MVD increases as Grade increases while the relation between MVD and recurrence has not been proved. It was concluded that the tumor grade and MVD are valuable to predict prognosis in superficial and invasive bladder tumors while quantification of angiogenesis does not help in the prediction of recurrence in superficial and invasive bladder cancer. However additional studies may be helpful to clarify further role of vascularity and asses the utility of angiogenic agents in treatment of urinary bladder tumors.