VERTICAL TRANSMISSION OF TOXOPLASMOSIS FROM THE MOTHER TO THE FETUS AND HEPATITIS C VIRUS CO-INFECTION
MOHAMED S. YOUNIS, ALI E.ALI, AMINA I. ABDEL-MABOUD,KHALID GHAITH AND AHLAM F.EL-SADEK
Department of Medical Parasitology, Benha Faculty of Medicine, Egypt
Aim: The present study was conducted to detect the occurrence of vertical transmission of toxoplasmosis from infected mothers to their babies and its relation to Hepatitis C Virus infection (HCV).Patients and methods: The study was performed on 70 women and their infants. Blood samples from the mothers and cord blood samples were taken at time of delivery .These samples were examined for detection of HCV antibodies by using HCV one step device and detection of anti-Toxoplasma specific IgG and IgM by enzyme linked immunosorbent assay.Results: Out of 70 cord blood samples; 5 cases (7.1%) were seropositive for HCV antibodies, out of them 4(80%) were positive for anti-Toxoplasma IgG antibodies and 1(20%)was negative for anti-Toxoplasma IgG antibodies .Out of 65 negative cases for HCV antibodies 32 cases (49.2%) were positive for anti Toxoplasma IgG antibodies and 33 cases (50.8%) were negative for anti- Toxoplasma IgG antibodies. Out of 70 maternal blood samples, 7 cases (10%) were seropositive for anti-Toxoplasma IgM antibodies one case of them her cord blood sample (1.4%) was seropositive for anti-Toxoplasma IgM antibodies .Conclusion: This study concluded that seropositivity of anti-Toxoplasma IgG antibodies among HCV positive cases was higher than that among HCV negative cases which may denote that toxoplasmosis is a risk factor for HCV infection, also positive IgM antibodies suggesting vertical transmission of toxoplasmosis. It is recommended to do a large population based study to elucidate the relation between toxoplasmosis and HCV infection, also antenatal screening programs for pregnant women to control the infection.