EFFECT OF ALBENDAZOLE ON THE TEGUMENT OF FASCIOLA HEPATICA OBTAINED FROM A CASE OF HUMAN FASCIOLIASIS
Maha Sayed I. Shaheen, Abeer E. Mahmoud and Amal M. Abdo Elmatery
Department of Parasitology Faculty of Medicine, Assiut University
Fascioliasis an emerging zoonotic infection of humans. A complete understanding of the micromorphological features of the tegument is important in developing any drug that can damage the parasite tegument.In this study, the susceptibility of Fasciola hepatica to treatment with albendazole was investigated. Surface changes to flukes were assessed by scanning electron microscopy (SEM), blebbing, swelling and furrowing of the tegument were observed. Surface changes generally were more severe in the cephalic region of the fluke and on the dorsal surface. The present work showed the effect of albendazlole on the cuticle of Fasciola hepatica detected accidentally in the bile ducts of a female patient presenting with biliary obstruction.The surface changes might raise the possibility that albendazole is an effective fasciolicidal drug.