A STUDY OF THE FUNCTIONAL AND STRUCTURAL CHANGES IN SKELETAL MUSCLES IN RESPONSE TO ANEMIC HYPOXIA INMALE ALBINO RATS
Shebl Ramadan Samaha, Gamal Soliman El-Gharabawi* and Mohamed Abdul-Haye Autifi **
Physiology, *Histology and **Anatomy Departments, Faculty of Medicine, Al-Azhar University
Anemia is a common debilitating condition associated with many clinical manifestations including easy fatigability and diminished oxygen supply to the tissues. Skeletal muscle fibers, like any kind of cell, need a continuous supply of oxygen and nutrients to be able to carry out their vital functions. It has been reported that despite exposure to hypoxia, skeletal muscle cells can alter their metabolism, proliferation and differentiation programs in response to hypoxia. The present work was designed to study the possible functional and structural alterations in skeletal muscles in response to anemic hypoxia in male albino rats. It was noted that exposure to anemic hypoxia led to significant changes in the metabolic parameters in addition to great morphological changes of the skeletal muscles in anemic rats. Continuous researches are recommended for more evaluation of interplaying factors which may participate with anemic hypoxia in the production of these physiological and anatomical changes in the skeletal muscles of anemic rats.