THE EFFICACY OF CURCUMIN TO AMELIORATE INDUCED HISTOPATHOLOGICAL CHANGES IN HEART OF RATS TREATED WITH AN INSECTICIDE
Amal Attia El-Morsy Ibrahim
Dept. of Zoology, Faculty of Women, for Arts, Education and Science, Ain Shams University, Cairo, Egypt.
Agrocide is a man-made pesticide extensively used in agriculture purposes. Human exposure to agrocide occurs via food, soft drinks and water. The present study was designated to clarify the antioxidant effect of curcumin and if it could ameliorate the side effects of agrocide on histopathological changes of rat heart and some antioxidants enzymes, beside the myocardial creatine kinase endothelin-1. Administration of agrocide (10 mg/kg/day) caused myocardial damage characterized by cytoplasmic vacuolization and myofibril disarrangement and loss, which was authenticated with the increase in indothelin-1 levels. Lipid peroxidation and catalase activities of the heart were increased, with a decrease in superoxide dismutase and glutathione levels in agrocide treated rats. The cardioprotective effect of curcumin (80 mg/kg/day) appeared in the improved histological picture of the cardiac tissue and the decrease in endothelin-1 levels.Conclusions: This is the first study to report the protective effect of curcumin on agrocide-induced oxidative stress in the heart. The observations have significant clinical relevance, as endothelin-1 plays a key role in the pathogenesis of cardiovascular disorders.