A STUDY OF THE EFFECT OF CHLORPHENIRAMINE MALEATE, FAMOTIDINE AND RANITIDINE ON OOGENESIS IN FEMALE ALBINO RATS
Cherine Maurice *, Hoda W. El-Gawly*, Nadia Abou –Zaid Ahmed *, Galal Lotfy**, Alaa saad El Din***
Pharmacology*, Gynaecology & obstetrics**, and Clinical pharmacology*** Departments, Faculty of Medicine, Suez Canal University
During their fertility period, females may require treatment with histaminergic receptors antagonists. So, their possible effects on oogenesis should be investigated to know their remote effect on female fertility. This work aimed to investigate the effects of histaminergic receptors antagonists (Chlorpheniramine maleate, ranitidine and famotidine) on the process of oogenesis and on hormonal profile. Mature female albino rats (180-200 gm) were chosen due to similarity of mechanisms involved in oogenesis, maturation of the Graafian follicles and ovulation in the human and due to their short estrous cycles. Rats were divided into 4 groups (13 rats /group): Group 1:-received saline 0.9% intramuscular daily for four weeks (control group). Group 2:- received Chlorpheniramine maleate 0.35 mg/Kg intramuscular daily for four weeks. Group 3:- received Ranitidine 8 mg/Kg intramuscular daily for four weeks. Group 4:- received Famotidine 10 mg/Kg intramuscular daily for four weeks. Chorpheniramine maleate and ranitidine decreased the process of oogenesis, maturation of graafian follicle and ovulation. Since the effect of Chorpheniramine maleate was less than that of ranitidine and famotidine, we concluded that effect of H2 antagonists on inhibition of ovulation is more than H1 antagonists. Otherwise, famotidine can be used as H2 antagonist rather than ranitidine as ranitidine impair ovulation more than famotidine. Both histaminergic antagonists inhibit oogenesis, so avoid usage if pregnancy is desired. H2 antagonists inhibit oogenesis more than H1 antagonist. The effect of chorpheniramine maleate is less than that of ranitidine and famotidine on inhibition of ovulation. Ranitidine impair ovulation more than Famotidine.