EFFECT OF CHLORAMPHENICOL ON THE LIVER AND KIDNEY OF RATS
Afnan M. Amer
Department of Zoology , Girls College for Arts, Science And Education, Ain Shams Univeristy
The toxic effect of chloramphenicol on the liver and kidney was studied in laboratory Wistar rats. Sixteen adult rats divided into two groups were used. Ten animals in the test group were administered chloramphenicol orally in a recommended dosage of 25 mg/kg body weight given once daily for a period of 16 days. The 6 animals in the control group were only administered physiological saline (0.9% NaCl) orally over the same period of time. Serum enzymes and levels of serum bilirubin, urea, and creatinine were evaluated to establish any hepatic or renal dysfunction. There was statistically significant increase in aspartate aminotransferase (p<0.05) and alanine aminotransferase (p<0.001) serum levels in the test animals. The increase in serum alkaline phosphatase was not statistically significant (p>0.05). Hyperbilirubinaemia was observed in the rats administered chloramphenicol, the difference in the mean value of the test and control animals was significant for total and conjugated bilirubin (Total bilirubin p<0.01; Conjugated bilirubin p<0.05). Serum urea and creatinine levels were elevated in the test animals, the increase is only statistically significant for serum urea (p<0.05) but not significant for creatinine (p>0.05). It was concluded that chloramphenicol may not be nephrotoxic but may have toxic effects on the liver.