EFFECT OF VITAMIN C AND ZINC ON LIPID PROFILE IN MALE ALBINO RATS TREATED WITH LEAD ACETATE
Zeinab H. Kamel
Department of Zoology, Faculty of Science, Cairo University
The aim of the present study was to investigate the possible protective role of vitamin C and zinc against chronic lead toxicity in male albino rats. Animals were divided into three groups: the first one was a control group; the second group received an oral dose of lead acetate as 20 mg/kg body weight daily for successive 20 days and the third group received the same lead acetate dose in combination with vitamin C (50 mg/animal) and zinc sulphate (50 mg/kg body weight) after one hour of lead administration by gastric intubation daily. At the end of 5, 10, 15 and 20 days of treatments, the contents of total lipids, cholesterol, triglycerides and phospholipids were estimated in serum and liver homogenate of treated rats. The lead toxicity induced remarkable alterations in the lipid parameters, which were observed after different periods of administration. Combined treatments of lead-exposed animals with vitamin C and zinc showed a marked improvement of some lipid parameters. These experimental results indicated that vitamin C and zinc caused a moderate ameliorative effect against toxic effects of lead on lipid metabolism.