INTERLEUKIN-12 (IL-12) IN TOXOPLASMOSIS CASES
Ali E. Ali, Azza M.S., El-Hamshary, Amina I. Abdel-Maboud, Rabab F. Mohamed, Amany El-Fakahany and Eman Abdel Rahman
Department of Parasitology, Faculty of medicine, Benha University
One hundred and fifty random samples from in patients at the department of gynecology and obstetrics were screened by indirect hemagglutination antibody (IHA) technique for toxoplasmosis. The positive, 67 (44.6%) were divided according to history of previous abortion to group I (37 cases, 7 cases were neglected) with no history of abortion and group II (30 cases) with a history of abortion. A third negative group (10) was taken as control. The 3 groups were tested by ELISA for anti-Toxoplasma IgG, IgM antibodies and IL-12 level. IgG antibodies were detected in 83% (25) in group I and 70% (21) in group II. IgM antibodies were detected in 6.6% (2) in group I only. There was no significant difference between mean (OD) of IL-12 in groups I, II and III. There was insignificant difference between mean IL-12 (OD), age, gravidity and parity. There was a significant difference between IL-12 mean OD, positive and negative IgG, anti-Toxoplasma antibody cases. There was insignificant difference between IL-12 mean (OD) and positive and negative anti-Toxoplasma IgM antibodies cases. It was concluded that the difference of statistical significance between mean (OD) of (IL-12) and positive and negative anti-Toxoplasma IgG antibody cases indicate their importance in screening for early control, minimizing complication and improving prognosis.