A COMPARATIVE STUDY BETWEEN THE ANTIOXIDANT EFFECT OF EMBLICA OFFICINALIS AND ITS TANNOIDS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Asaad El-Mileegy1, Ahmed El-Gendy1, Amal Seleem1, Sahar Abd-El-Rasheed1
Departments of 1Physiology, and 1Biochemistry, Faculty of Medicine, Mansoura University,
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University
Background: Plants have been reported to play an important role in the discovery of new drugs for the treatment of human diseases.Aim of the Work: This study was designed to investigate the antioxidant effect of Emblica in streptozotocin-induced diabetic rats in comparison with that of Emblica tannoids.
Materials and methods: Forty male albino rats were divided into 4 groups (control, diabetic, diabetic then Emblica, diabetic then tannoids); each group consisted of 10 rats. Before and after 8 weeks of the experiments we measured the levels and activity of the antioxidant enzymes and the products of lipid peroxidation [thiobarbituric acid-reactive substances (TBARS), and cholesteryl ester hydroperoxides (CEOOH)].
Results: Emblica and its tannoids increased the antioxidant enzymes. Furthermore, the antioxidant enzymes were higher in the tannoids group compared to the Emblica group. On the other hand, intake of Emblica and its tannoids decreased plasma TBARS and CEOOH.
Conclusion: These results strongly suggest that tannoids suppress diabetes-induced oxidative stress more effectively than the intake of the same amount of Emblica alone.