FECAL CALPROTECTIN AND FECAL HEMOCCULT BLOOD IN PATIENTS WITH CHRONIC DIARRHEA IN INFLAMMATORY BOWEL DISEASE
Sherif Ezat, Mohamed El Bedewy, Mahmoud Selim and Mohamed Kamal Zahra*
Departments of Internal Medicine and *Clinical pathology, Faculty of Medicine, Tanta University
Introduction: Inflammatory bowel disease (I.B.D), Ulcerative Colitis and Crohn's disease are the most common causes of chronic diarrhea.The protein calprotectin is non-glycosylated human protein that is usually elevated from five to thousand times in patients with inflammatory bowel disease.
Aim of the work: This work aimed to assess and compare performance of fecal calprotectin and fecal hemoglobin in patients with inflammatory bowel disease.
Results: There was a statistical significant elevation of fecal calprotectin level in patients with inflammatory bowel disease, also high sensitivity and specificity of fecal calprotectin compared with endoscopic examination in detecting inflammatory bowel disease.
Conclusion: Fecal calprotectin value can be used to diagnose, evaluate activity and monitor of inflammatory bowel disease. Fecal calprotectin is more superior to fecal hemoccult in diagnosis of inflammatory bowel disease.