E OF INFECTION, INCIDENCE AND SUSCEPTIBILITY PATTERNS OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN SAUDI ARABIA
Mohammed Ali M. Marie
Clinical Laboratory Department, College of Health Sciences, Riyadh, Saudi Arabia
Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. The prevalence of MRSA in many countries is increasing. In some hospitals, more than half of all S. aureus isolates are MRSA. MRSA strains are becoming increasingly multiresistant, and have recently developed resistance to vancomycin, which has been used successfully to treat MRSA for more than 30 years. In-vitro determination of resistance patterns of S. aureus is critical in terms of administering suitable antimicrobial treatments. The objective of this study was to identify the frequency of MRSA from various clinical samples and resistance patterns against various antibiotics used broadly for treatments. All isolated S. aureus strains were identified using standard procedures and tested for oxacillin resistance according to methods of the National Committee for Clinical Laboratory Standards. A total of 3329 coagulase-positive Staphylococci and 1134 MRSA were isolated. The major sources of MRSA were the upper respiratory tract. Surgical wounds and burn, accounted for 852 (75.87%) of all isolates. One hundred and eleven MRSA (9.8%) were from patients with pneumonia, and 74 (5.64%) blood of patients with sepsis. The rest of the isolates were from catheter tips, urine samples, patients with eye and ear infection. The isolates were found to be sensitive against vancomycin. Although methicillin resistance increased in S. aureus strains, suggesting an effective alternative treatment for Staphylococcus aureus infections. These results indicated that vancomycin seemed to be the only antimicrobial agent effective against MRSA. It could be the drug of choice in treating multidrug resistant MRSA infection.