NEUROPROTECTIVE EFFECT OF TIRON ON PARKINSON'S DISEASE
Shrook A. Mohamed, Dalia H. El-Kashef, Manar A. Nader
Department of Pharmacology and Toxicology, Faculty of Pharmacy,Mansoura University, Mansoura, 35516, Egypt
Parkinson's disease is a common, slowly progressive neurodegenerative disorder resulting from the degeneration of dopaminergic neurons in the substantia nigra. In the current study, we aim to investigate the neuroprotective effect of tiron against 1 -methyl- 4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinsonism. MPTP (30 mg/kg, ip) was injected in mice daily for 5 consecutive days. Mice were treated with tiron (140 mg/kg, ip) for 10 consecutive days, starting 5 days before MPTP injection. At the end of the experiment, behavioral tests were conducted to evaluate the neuroprotective effect of tiron. Tiron significantly inhibited the neurodegenerative deterioration induced by MPTP.