EVALUATION OF THE THERAPEUTIC OR PROTECTIVE ROLE OF OMEGA 3 FISH OIL AGAINST THE PROGRESSION OF RHEUMATOID ARTHRITIS IN MALE ALBINO RATS (HISTOLOGICAL STUDY)
Sanaa M.R. Wahba, Samira A. Abdel Mageid and Nadia Noble-Daoud Aniss
1Zoology Department-Faculty of Women for Arts, Science and Education - Ain Shams University, Cairo, Egypt.
The effect of omega 3 fish oil to alleviate rheumatoid arthritis (RA) alterations in haemapoietic organs in rats was studied. A total of 96 adult male albino rats were equally divided into 5 groups, of 18 rats each: A control group, group of rats receiving omega 3 fish oil at a dosage of 1000 mg/kg b.wt. /day by oral injection, RA group injected with 150 μl pristane, omega 3 fish oil groups administered pristane pre and post induction for RA to assess its prophylactic and curative activities in RA rats. All groups were treated for 60 days experimental duration. The protection group given omega 3 fish oil for two month exhibited partial recovery, mild lesions appeared as dilatation in lymphatic sinusoids, and limited degenerative areas were also noticed. These changes were accompanied by histological alterations in the spleen such as haemorrhage, lymphocytic infiltration and presence of hyaline material in red pulp. No evidence of splenic or lymph node tissue repair took place during the whole experimentation period after treatment with omega 3 fish oil where more pronounced histological findings were evidenced. Therefore, it may be suggested that protection with omega 3 fish oil may minimize the dreadful effect of rheumatoid arthritis on immune system target organs.