EFFECT OF TRAMADOL ON THE CEREBELLAR CORTEX OF ADULT MALE ALBINO RAT AND THE POSSIBLE PROTECTIVE ROLE OF MELATONIN: HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
Tarek Ibrahim Abd El-Galil
Department of Anatomy and Embryology, Faculty of Medicine, Cairo University
Introduction: Tramadol is synthetic opioid used to lighten pain. Among its adverse reactions is neurodegeneration of cerebellar cortex. Pineal gland is source of melatonin which has a role in modulation of drug addiction. Aim of the work: to clarify the ameliorating effect of melatonin against tramadol- induced cerebellar damage. Material and methods: This study was done on 50 adult male albino rat and they were categorized into 5 equal groups (10 rats each): Group I (Control), Group II (Low dose tramadol group), Group III (high dose tramadol group), Group IV (Low dose tramadol and melatonin group) and Group V (high dose tramadol and melatonin group). Results: Examination of group II revealed affection of Purkinjie cells in the form of cytoplasmic vacuolation and nuclear degeneration. However, group III exerted marked damage of Purkinjie cells. Melatonin treatment impressively improved these histological alterations particularly in group IV. Conclusion: Melatonin could improve histological alterations induced by tramadol in cerebellum.