PREDICTORS OF RECURRENCE FREE SURVIVAL AND OVERALL SURVIVAL IN BLADDER CANCER PATIENTS TREATED AT UROLOGY DEPARTMENT AL – AZHAR UNIVERSITY HOSPITALS
Hossam A. Shouman; Mohammed M. Badr; Sabri M. Khaled
Department of Urology Faculty of Medicine; Al-Azhar University
Background: Bladder cancer is a major health problem; challenges as regard diagnosis and treatment modalities are still present. Aim of the work: to study the oncological outcome; recurrence and survival predictors after treatment options of non invasive and invasive bladder cancer. Patients and methods: This is a data analysis study of patients diagnosed with urinary bladder carcinoma and treated in Al-Azhar University Hospitals (Al-Hussein and Bab-Alshaariah hospitals) during the period from January 2013 through December 2017. The study was conducted by reviewing the medical charts and calling the patients whenever possible to know their health status regarding bladder cancer. Demographic, clinical, laboratory, outcome data were collected. Results: Patient prognosis improved with each additional year survived after surgery even after a long-term period. Given that about 50% of patients die in the first 2 years after radical cystectomy (median survival: 22.7 mo), surviving patients beyond this period may expect a better prognosis. Thus the risk of dying of bladder cancer after surgery is not constant over time, with most deaths occurring in the first 2 years. Therefore, the 5 years survival probability of a patient who survives this critical period improves as compared with that calculated at baseline. This is important because many patients want to know how their chances of long term survival might improve. Recurrence free survival was 57.2 month. The overall survival 83% at one year; 70.0% at three years and 64.0% at five years. Conclusion: the results of the present study highlighted the clinical characteristics of urinary bladder cancer and results of the different modalities of treatment especially radical cystectomy with survival as the primary outcome.